Studies on the relation between heme and nucleic acid syntheses in erythroid cell. 3. Nucleolus of erythroblast, changes in relation with cell specialization.
نویسنده
چکیده
The disappearance of nucleolus has been traced in the rat erythroid cells in relation with the cell specialization under varying conditions, i. e. in anemia with or without treatment by bromouracil and aminopterin. To make the findings more reliable the observations have been made on tissue section as well as on the smeared samples as the nucleolus becomes often indistinct in smeared cell. The results indicate that under anemic condition nucleolus is lost by the late basoplilic stage. Treatment with bromouracil retained the nucleoli and cytoplasmic basophilicity till later stage of cell specialization suggesting some similar mechanism of RNA disintegration both in nucleolus and cytoplasm. ∗PMID: 4241733 [PubMed indexed for MEDLINE] Copyright c ©OKAYAMA UNIVERSITY MEDICAL SCHOOL Acta Med. O:,ayama 23, 1-6 (1969) STUDIES ON THE RELATION BETWEEN HEME AND NUCLEIC ACID SYNTHESES IN ERYTHROID CELL III. NUCLEOLUS OF ERYTHROBLAST, CHANGES IN RELATION WITH CELL SPECIALIZATION
منابع مشابه
Studies on the relation between heme and nucleic acid syntheses in erythroid cell. I. Effects of aminopterin and bromouracil on hemopoiesis and hemoglobin synthesis in anemic rat.
For the purpose to see how the suppression of the nucleic acid synthesis disturbs the cell specialization process the author observed the erythroid cell specialization in anemic rats by treating them with aminopterin (AP) and 5-bromouracil (BU). The observations indicate that the AP injection inhibits the mitosis of erythroblast with the acceleration of hemoglobin synthesis and the denucleation...
متن کاملStudies on the relation between heme and nucleic acid syntheses in erythroid cell. II. Nucleic acid synthesis in erythroblast of anemic rat treated with aminopterin and bromouracil.
With the bone marrow of anemic rats, which had received the repeated injections of phenylhydrazine once a day for three to four days, the effects of aminopterin and bromouracil on the nucleic acid metabolism of erythroblasts were observed in vivo experiment. The injection of aminopterin suppreed DNA synthesis with the lowered labeling index as observed by the incorporation of Hthymidine into DN...
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عنوان ژورنال:
- Acta medicinae Okayama
دوره 23 1 شماره
صفحات -
تاریخ انتشار 1969